There are
1,207 mi
from Appleton, WI to Gainesville, FL
That's the driving distance. It would take 23 hours 3 mins to go from Appleton, Wisconsin to Gainesville, Florida.
The flight distance (direct flight from Appleton, WI to Gainesville, FL) is 1,063.21 mi.
1,207 mi = 1,942.26 kms