There are
559 mi
from Appleton, WI to Chillicothe, OH
That's the driving distance. It would take 10 hours 48 mins to go from Appleton, Wisconsin to Chillicothe, Ohio.
The flight distance (direct flight from Appleton, WI to Chillicothe, OH) is 440.57 mi.
559 mi = 898.99 kms