There are
2,164 mi
from Antioch, CA to Sikeston, MO
That's the driving distance. It would take 1 day 13 hours to go from Antioch, California to Sikeston, Missouri.
The flight distance (direct flight from Antioch, CA to Sikeston, MO) is 1,760.33 mi.
2,164 mi = 3.22 kms