There are
1,875 mi
from Antioch, CA to Kirksville, MO
That's the driving distance. It would take 1 day 8 hours to go from Antioch, California to Kirksville, Missouri.
The flight distance (direct flight from Antioch, CA to Kirksville, MO) is 1,567.10 mi.
1,875 mi = 1.61 kms