There are
2,045 mi
from Antioch, CA to Edwardsville, IL
That's the driving distance. It would take 1 day 11 hours to go from Antioch, California to Edwardsville, Illinois.
The flight distance (direct flight from Antioch, CA to Edwardsville, IL) is 1,716.71 mi.
2,045 mi = 3,291.37 kms