There are
305 mi
from Ann Arbor, MI to Sycamore, IL
That's the driving distance. It would take 5 hours 51 mins to go from Ann Arbor, Michigan to Sycamore, Illinois.
The flight distance (direct flight from Ann Arbor, MI to Sycamore, IL) is 254.07 mi.
305 mi = 490.64 kms