There are
814 mi
from Ann Arbor, MI to Sioux Falls, SD
That's the driving distance. It would take 15 hours 4 mins to go from Ann Arbor, Michigan to Sioux Falls, South Dakota.
The flight distance (direct flight from Ann Arbor, MI to Sioux Falls, SD) is 660.80 mi.
814 mi = 1,309.75 kms