There are
578 mi
from Ann Arbor, MI to Cape Girardeau, MO
That's the driving distance. It would take 10 hours 42 mins to go from Ann Arbor, Michigan to Cape Girardeau, Missouri.
The flight distance (direct flight from Ann Arbor, MI to Cape Girardeau, MO) is 460.37 mi.
578 mi = 930.91 kms