There are
4,355 mi
from Anchorage, AK to Cayce, SC
That's the driving distance. It would take 3 days 15 hours to go from Anchorage, Alaska to Cayce, South Carolina.
The flight distance (direct flight from Anchorage, AK to Cayce, SC) is 3,500.32 mi.
4,355 mi = 6.44 kms