There are
242 mi
from Ames, IA to La Crosse, WI
That's the driving distance. It would take 4 hours 32 mins to go from Ames, Iowa to La Crosse, Wisconsin.
The flight distance (direct flight from Ames, IA to La Crosse, WI) is 172.24 mi.
242 mi = 390.15 kms