There are
1,327 mi
from Amarillo, TX to Orangeburg, SC
That's the driving distance. It would take 23 hours 44 mins to go from Amarillo, Texas to Orangeburg, South Carolina.
The flight distance (direct flight from Amarillo, TX to Orangeburg, SC) is 1,200.13 mi.
1,327 mi = 2,136.13 kms