There are
1,105 mi
from Amarillo, TX to Middletown, OH
That's the driving distance. It would take 20 hours 6 mins to go from Amarillo, Texas to Middletown, Ohio.
The flight distance (direct flight from Amarillo, TX to Middletown, OH) is 1,000.27 mi.
1,105 mi = 1.61 kms