There are
1,303 mi
from Amarillo, TX to Lexington, SC
That's the driving distance. It would take 23 hours 1 min to go from Amarillo, Texas to Lexington, South Carolina.
The flight distance (direct flight from Amarillo, TX to Lexington, SC) is 1,172.30 mi.
1,303 mi = 2,097.69 kms