There are
1,016 mi
from Amarillo, TX to Jeffersonville, IN
That's the driving distance. It would take 18 hours 7 mins to go from Amarillo, Texas to Jeffersonville, Indiana.
The flight distance (direct flight from Amarillo, TX to Jeffersonville, IN) is 914.35 mi.
1,016 mi = 1,635.60 kms