There are
1,075 mi
from Amarillo, TX to Irvine, CA
That's the driving distance. It would take 18 hours 50 mins to go from Amarillo, Texas to Irvine, California.
The flight distance (direct flight from Amarillo, TX to Irvine, CA) is 914.71 mi.
1,075 mi = 1.61 kms