There are
1,866 mi
from Amarillo, TX to Holyoke, MA
That's the driving distance. It would take 1 day 10 hours to go from Amarillo, Texas to Holyoke, Massachusetts.
The flight distance (direct flight from Amarillo, TX to Holyoke, MA) is 1,638.05 mi.
1,866 mi = 1.61 kms