There are
1,254 mi
from Amarillo, TX to Greenwood, SC
That's the driving distance. It would take 22 hours 32 mins to go from Amarillo, Texas to Greenwood, South Carolina.
The flight distance (direct flight from Amarillo, TX to Greenwood, SC) is 1,117.61 mi.
1,254 mi = 1.61 kms