There are
1,501 mi
from Amarillo, TX to Depew, NY
That's the driving distance. It would take 1 day 3 hours to go from Amarillo, Texas to Depew, New York.
The flight distance (direct flight from Amarillo, TX to Depew, NY) is 1,344.39 mi.
1,501 mi = 1.61 kms