There are
2,274 mi
from San Francisco, CA to Madisonville, KY
That's the driving distance. It would take 1 day 15 hours to go from San Francisco, California to Madisonville, Kentucky.
The flight distance (direct flight from San Francisco, CA to Madisonville, KY) is 1,901.84 mi.
2,274 mi = 3.22 kms