There are
2,484 mi
from San Francisco, CA to Knoxville, TN
That's the driving distance. It would take 1 day 19 hours to go from San Francisco, California to Knoxville, Tennessee.
The flight distance (direct flight from San Francisco, CA to Knoxville, TN) is 2,116.71 mi.
2,484 mi = 3.22 kms