There are
3,046 mi
from San Francisco, CA to Key Biscayne, FL
That's the driving distance. It would take 2 days 6 hours to go from San Francisco, California to Key Biscayne, Florida.
The flight distance (direct flight from San Francisco, CA to Key Biscayne, FL) is 2,594.82 mi.
3,046 mi = 4.83 kms