There are
1,690 mi
from San Diego, CA to Opelousas, LA
That's the driving distance. It would take 1 day 5 hours to go from San Diego, California to Opelousas, Louisiana.
The flight distance (direct flight from San Diego, CA to Opelousas, LA) is 1,479.50 mi.
1,690 mi = 1.61 kms