There are
324 mi
from Omaha, NE to Hannibal, MO
That's the driving distance. It would take 6 hours 11 mins to go from Omaha, Nebraska to Hannibal, Missouri.
The flight distance (direct flight from Omaha, NE to Hannibal, MO) is 266.09 mi.
324 mi = 521.83 kms