There are
1,646 mi
from Mesa, AZ to Owensboro, KY

That's the driving distance. It would take 1 day 5 hours to go from Mesa, Arizona to Owensboro, Kentucky.

The flight distance (direct flight from Mesa, AZ to Owensboro, KY) is 1,416.67 mi.

1,646 mi = 1.61 kms