There are
2,204 mi
from Mesa, AZ to Niagara Falls, NY
That's the driving distance. It would take 1 day 16 hours to go from Mesa, Arizona to Niagara Falls, New York.
The flight distance (direct flight from Mesa, AZ to Niagara Falls, NY) is 1,886.20 mi.
2,204 mi = 3.22 kms