There are
1,777 mi
from Louisville, KY to Mesquite, NV
That's the driving distance. It would take 1 day 7 hours to go from Louisville, Kentucky to Mesquite, Nevada.
The flight distance (direct flight from Louisville, KY to Mesquite, NV) is 1,548.32 mi.
1,777 mi = 1.61 kms