There are
394 mi
from Chesapeake, VA to Spartanburg, SC

That's the driving distance. It would take 7 hours 37 mins to go from Chesapeake, Virginia to Spartanburg, South Carolina.

The flight distance (direct flight from Chesapeake, VA to Spartanburg, SC) is 340.07 mi.

394 mi = 633.71 kms